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Journal Articles

Indications and results for the EXOGEN ultrasound system in the management of non-union: a 59-case pilot study.

Orthopaedics, Traumatology, Surgery & Research (OTSR),
Roussignol X, Currey C, Duparc F, Dujardin F.

This pilot series sought to assess the use of EXOGEN in the treatment of femoral or tibial non-unions. The 88% bone healing rate, which is higher than in traditional surgery and with a unit cost at least 60% lower, supports advocating first-line implementation in non-unions of less than 10mm with stable osteosynthesis.

Abstract available at PubMed.gov.

Low-intensity pulsed ultrasound in the treatment of nonunions.

The Journal of Trauma,
Nolte PA, van der Krans A, Patka P, Janssen IM, Ryaby JP, Albers GH

This study4 found that EXOGEN can be useful in the treatment of challenging, established non-unions, with an 86% overall healing rate.

Full article available at PubMed.gov.

Low-intensity pulsed ultrasound: effects on nonunions.

Ultrasound in Medicine and Biology,
Gebauer D, Mayr E, Orthner E, Ryaby JP

In this study,16 67 non-union fractures were treated with EXOGEN. After daily 20-minute treatments, 85% of the non-union cases were healed.

Full article available at PubMed.gov.

Improved healing response in delayed unions of the tibia with low-intensity pulsed ultrasound: results of a randomized sham-controlled trial.

BMC Musculoskeletal Disorders,
Schofer MD, Block JE, Aigner J, Schmelz A

In the first Level I study21 regarding non-union heal rates, 51 patients with tibia delayed unions were treated with EXOGEN. Mean improvement in their bone mineral density was 1.34 times greater than that of patients who received sham device treatment.

Full article available for download or at PubMed.gov.

Acceleration of tibia and distal radius fracture healing in patients who smoke.

Clinical Orthopaedics and Related Research,
Cook SD, Ryaby JP, McCabe J, Frey JJ, Heckman JD, Kristiansen TK

This study12 finds that smokers with indicated* tibia and radius fractures heal faster when using EXOGEN—41% faster for tibia fractures and 51% faster for distal radius fractures.

Full article available at PubMed.gov.

Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound.

The Journal of Bone and Joint Surgery,
Heckman JD, Ryaby JP, McCabe J, Frey JJ, Kilcoyne RF

This study2 demonstrates the efficacy of the EXOGEN bone healing system. Healing time for fresh fractures was found to be significantly accelerated when EXOGEN was applied for 20 minutes a day, with 94% of the fractures in the EXOGEN group healed after 150 days.

Full article available at PubMed.gov.

Accelerated healing of distal radial fractures with the use of specific, low-intensity ultrasound. A multicenter, prospective, randomized, double-blind, placebo-controlled study.

The Journal of Bone and Joint Surgery,
Kristiansen TK, Ryaby JP, McCabe J, Frey JJ, Roe LR

In this study,3 60 patients with fresh radius fractures used either EXOGEN or a placebo device for 10 weeks. EXOGEN users had a significantly shorter time to union, with acceleration demonstrated at every stage of healing.

Full article available at PubMed.gov.

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